Apoptosis

Apoptosis

Programmed cell death
Energy dependent process, requires specific protein synthesis (p53.Chr17). Does not stimulate inflammatory response
May be physiological or pathological

Physiological	Pathological
Embryology: finger development, development gut lumens Thymus: physiological degeneration Endometrial cycle Menopause	Following cellular damage: virus, bacteria, RT, drugs Reaction to normal cell cycle In response to tumours

Apoptosis Genes

Promotors	Un promotors
p53 - Chromosome 17 c-myc BrCA1/2	bcl-2

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