Inflammatory Markers
Classification of inflammatory mediators
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Substances stored irrespective of need and released when required
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Histamine
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Serotonin
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Substances synthesized in cells as required when inflammatory events dictate
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Leucotrines
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Prostaglandins
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Cytokines
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Cascades that are activated as part of the inflammatory response
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Clotting cascade
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Complement cascade - opsonins, chemoattractants, anaphylactic agents
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Kinin cascade
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Prime plasma-derived mediators in acute inflammation
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Fibrin-related peptides and plasmin
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Kallikrein and bradykinin
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C3a C5a
CRP
C-reactive protein
Half-life ~6hours
Marker of acute inflammation
Protein derived produced in liver
Functionally similar to IgG (but not specific)
