Carcinogenesis
Carcinogenesis
- Remote carcinogen
- Precursor of carcinogenic agent
- Proximate carcinogen
- Metabolite of remote carcinogen with potential
- Needs further modification into ultimate
- Ultimate carcinogen
- DNA interaction causes cancer
B-naphthylamine - ingested and absorbed from small bowel, metabolised in liver, made soluble, excreted by kidney and causes cancer in bladder (after being gluconurated by bladder epithelium).
Initiator: Alters DNA making it abnormal
Promoter: Leads to altered gene expression (eg hormones)
